Hola de nuevo,
Aquí tiene tres artículos que me parece que le podrían ayudar. Como inconveniente: están en inglés, pero en las bases de datos bibliográficas médicas los artículos suelen estar en inglés.
Los 3 son interesantes, pero en concreto el tercero es la revisión más reciente que he encontrado sobre el metabolismo del etanol y, por supuesto, habla de la influencia de la comida y del tipo de comida en él.
1. J Stud Alcohol. 1976 Sep;37(9):1197-214.
Food effects on absorption and metabolism of alcohol.
Sedman AJ, Wilkinson PK, Sakmar E, Weidler DJ, Wagner JG.
The concomitant ingestion of various foods with alcohol resulted in a decreased area under the blood alcohol concentration curve, a lower peak concentration and an increased time to reach peak. Michaelis-Menten kinetics indicated a decreased alcohol metabolism rate after the ingestion of carbohydrates or fats.
2. Res Commun Chem Pathol Pharmacol. 1976 Apr;13(4):713-22.
Effects of solid food on blood levels of alcohol in man.
Lin Y, Weidler DJ, Garg DC, Wagner JG.
Forty-five ml of 95% alcohol, diluted to 150 ml with orange juice, was taken orally by six adult male volunteers under the following conditions: A (fasting), B (following a light breakfast), C (following a heavy breakfast), D (following a steak meal), E (alcohol 1 hr after a heavy breakfast), and F (alcohol 1 hr before a heavy breakfast). Using treatment A as a reference, the average area under the blood alcohol, time curve was reduced by 36, 63, 55, 56, and 18% for treatment B through F, respectively. The reduction in area is attributed to two factors: (a) food reduced the efficiency of absorption of alcohol; and (b) food reduced the rate of absorption of alcohol, which, coupled with the operation of Michaelis-Menten elimination kinetics, contributed to the reduction in area. The latter effect is a result of changes in the ratio: instantaneous rate of metabolism/amount of alcohol in the body, which results in a smaller area when the rate of absorption is slow than when the rate of absorption is rapid. Using treatment A as a reference, the ratio of the average peak alcohol concentrations were: 1.0, 0.72, 0.35, 0.50, 0.49 and 1.11 for treatments A through F, respectively.
3. Pathol Biol (Paris). 2001 Nov;49(9):676-82.
Research advances in ethanol metabolism.
Ramchandani VA, Bosron WF, Li TK.
Department of Medicine, Indiana University School of Medicine, 975, W. Walnut Street, IB 424, Indianapolis, IN 46202-5121, USA. [email protected]
The pharmacokinetics of alcohol determines the time course of alcohol concentration in blood after the ingestion of an alcoholic beverage and the degree of exposure of organs to its effects. The interplay between the kinetics of absorption, distribution and elimination is thus important in determining the pharmacodynamic responses to alcohol. There is a large degree of variability in alcohol absorption, distribution and metabolism, as a result of both genetic and environmental factors. The between-individual variation in alcohol metabolic rates is, in part due to allelic variants of the genes encoding the alcoholmetabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). This review summarizes recent developments in the investigation of the following influences on alcohol elimination rate: gender, body composition and lean body mass, liver volume, food and food composition, ethnicity, and genetic polymorphisms in alcohol metabolizing enzymes as well as in the promoter regions of the genes for these enzymes. Evaluation of the factors regulating the rates of alcoholand acetaldehyde metabolism, both genetic and environmental, will help not only to explain the risk for development of alcoholism, but also the risk for development of alcohol-related organ damage and developmental problems.
Espero que esta información le sea de ayuda (Le he proporcionado los resúmenes porque no hay acceso a los artículos a no ser que se pague una suscripción de la que Justanswer no dispongo, y yo personalmente tampoco en estos momentos, pero usted mismo puede acceder a ellos a través la página www.pubmed.gov).